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Polymyalgia Rheumatica (PMR) | Last Active: Jul 23 10:03am | Replies (12)
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@dadcue
Thank you so much for your feedback and I will stay with this group.
After I finally got a Rheumatologist, I was started on Methotrexate. I sorta managed two weeks but I got horrible diarrhea. It took weeks for my system to settle down.
My infusion medication is Orencia and just had my first dose yesterday, 7/20/26. My most noticeable reaction was my bladder was hyperactive for over 12 hours. Clear urine mostly during this time.
I will continue to give updates but would like to hear from others that have taken this medication. Thanks!
Replies to "@dadcue Thank you so much for your feedback and I will stay with this group. After..."
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@betsyhase
Mayo Clinic has good information about Orencia. I don't know anything about it but I hope it works for you.
https://www.mayoclinic.org/drugs-supplements/abatacept-intravenous-route-subcutaneous-route/description/drg-20070783
I don't understand how it is determined which biologic will work and which one won't work other than the trial and error method. When you have both PMR and inflammatory arthritis it might be difficult for a single biologic to work for both conditions but you can't take 2 biologic medications.
I tried Actemra first and it worked well for PMR. When I switched to Humira, it didn't work so well for me. I needed to choose which biologic worked the best for me and I chose Actemra.
There are several kinds of seronegative inflammatory arthritis conditions and the symptoms overlap with PMR symptoms. I have both PMR and inflammatory arthritis and I can't tell which condition causes the most pain. However, inflammatory arthritis is said to cause more damage.
https://arthritissj.com/why-seronegative-rheumatic-diseases-are-difficult-to-diagnose/