The Big 3 are usually thought of as azithromycin (or clarithromycin), rifampin and ethambutol. Recent studies seem to show that possibly taking just two of these are just as effective. They take out the rifampin. The usual protocol is to take these 3 drugs either 3 times a week or every day depending on your diagnosis. Once you convert (negative sputum samples) you take them for a full year. If you don’t convert in 4 months (I think) they may add or substitute other drugs. As you can see it’s important to find a pulmonologist who is an expert. Once you do you will feel less overwhelmed (at least for me).