@tkw1 What estradiol dose and, as @singingbones asks, was your resulting blood serum estradiol level tested? Thanks tkw1y. Sorry to hear about your outcome, and your experience is very useful information.

Here are some excerpts from the below linked article to show why this is important:
"Limited data suggest that up to 20% of women are “poor absorbers” of transdermal estradiol. It is essential that ‘poor absorbers’ with subtherapeutic levels are prescribed higher doses ..."

"... there is substantial interindividual and intraindividual variation in estradiol pharmacokinetics, resulting in up to 10-fold differences in estradiol levels between women using the same dose patch or gel. ..."

Title: The range and variation in serum estradiol concentration in perimenopausal and postmenopausal women treated with transdermal estradiol in a real-world setting: a cross-sectional study
https://journals.lww.com/menopausejournal/fulltext/10.1097/gme.0000000000002459~the-range-and-variation-in-serum-estradiol-concentration-in
Dr. Doug Lucas also explains why dose, and testing for response, matters in this video.

I got mine tested through Jason Health and I was exactly on the mean dose-response for the patches that I was taking. The cost was $55 plus $18 collection fee but I had 3 other tests (incl CTX and P1NP) done at the same time that used the same collection.