@abd I have been on Actemra for years with good results. Last October my insurance company decided to deny coverage and said I should switch to Tyenne. I tried to persevere, but I was having side effects like large bruises at the site of injection and rashes that lasted right up to the next date of injection. I was also having increased flare-ups of my RA. I have PMR, GCA and RA. The only thing I can come up with for the difference between Tyenne and Actemra is that they probably have to change something in the make-up of the medication so they won't be copying Actemra's formula. I'm not a doctor, so I can only theorize. It may not affect you in the same way. It's certainly a lot less expensive.