The biggest problem is these two things (Cribriform pattern. Intraductal carcinoma)
I think you should definitely ask the pathologist whether the cribriform is large (>.25mm) Or Small. Large is much more aggressive.
A combination of large cribriform And intraductal Has really not been found to be fully treated by any current procedure. It has a very high chance of reoccurrence as your decipher score shows.
As a result of this, I personally would not be arguing with the doctor about how long I should be on ADT. You may want to stay on ADT and an ARPI for years. ADT for the recommended time could help suppress cancer growth. I know a lot of people that are on just Nubeqa, Since it allows them to have their testosterone, but still suppresses the prostate cancer. I’ve been on it for three years and I’ve been undetectable for 32 months after 16 years of prostate cancer. It has very few side effects, None for most people, So it’s a good solution for an aggressive case.
I personally have been on ADT for eight years. I have BRCA2, which is aggressive, so my oncologist feels I should stay on it. It does not cause life-changing problems. Fortunately, I don’t have fatigue and I have worked around all the other side effects. Not saying they are gone just saying I have Solutions for them.
Just some things to think about and discuss with your doctor.
@jeffmarc Jeff, how long can Nubeqa alone really work? It blocks androgen receptor sites on PCa cells but eventually don’t these cells find ways to bypass that blocking effect? They seem to find ways around everything else!😖
Another poster asked if anyone kept their PSA down with darolutamide ONLY, so this is part of that question.
Phil