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@jamie1957 Our stories are not all that different. RARP when I was 62 (2015). Gleason 3+4. I was undetectable (<0.1) for ten years. Then in June 2025 my PSA hit 0.11. I also had a nodule in my prostate bed that lit up like Christmas tree on a PSMA PET scan, but no mets beyond that were detected. I did 38 sessions of salvage IMRT (both prostate bed and pelvic lymph nodes) last fall (Sept-Nov). I did an usPSA test just before starting therapy that yielded 0.097. The IMRT went pretty well with only a few hiccups, and I haven’t had any lingering serious side effects, so far. PSA really hasn’t dropped yet. As I stated in a previous comment, I’ve had four usPSA tests since RT and they average to 0.097, with min of 0.086 and max of 0.113. Not what I expected, but I’ve since learned that it can take 2-5 years for your PSA to bottom after RT. My RO and urologist are not oncerned at this point, so I will just continue with quaterly PSA test and see where it goes. My optimistic interpretation is that the cancer is indolent (ten years before recurrence supports that), and if so the cancer cells are not dying from radiation damage because they are not dividing much. Whether my interpretation is right or not, I took the path of early intervention, like you, aiming for a better outcome than if I waited to hit 0.2.

Anyway, best wishes to you going forward with your salvage RT. “Full bladder and empty rectum” will be your daily mantra for a while.

Mel

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Replies to "@jamie1957 Our stories are not all that different. RARP when I was 62 (2015). Gleason 3+4...."

@melvinw
Thanks Mel. Good to know. Although I don’t think that the Radiation Therapy will be a walk in the park, I am pretty confident that I will handle it just fine. No talk of ADT so that’s good. I did not know that it could take a few years for the PSA’s to go down after RT so that is good to know too. I trust my Surgical Urologist and my RO so although I may have questions along the way, I am pretty comfortable with their assessments at this point. Thanks for the information.

@melvinw Very similar to my case. In 2015, I was 68 at the time when I had the surgery. The PSA remained at 0.05 for 14 months after the surgery until it rose to 0.09, then 0.14. At this point I was given 40 radiation sessions and on Lupron for 6 years. In 2019 my cancer was diagnosed as terminal stage 4 with a survival of 4 years. My PSA from 2017 to 2025 was about 0.30. Since I was still alive, in August 2023, I asked my oncologist to stop medication until the PSA raises to 1. He accepted. My last PSA was 0.68 and my oncologist ordered a PET scan for this August.
I hope this chronological information helps you to get any idea.