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Aromatase Inhibitor

Breast Cancer | Last Active: 1 hour ago | Replies (27)

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I did. First, was on Anastrozole for about 4 months, switched to Letrozole due to severe daily headaches.
Letrozole was no improvement for me but hung in there for about 5 months. Finally since March I am on exemestane. The headaches have subsided a great deal. I still get them but can cope. As far as joint pain, I have had it with all 3 AIs but I am tolerating this pain which is not constant. No walk in the park but it's doable.
The headaches were really incapacitating for me. Thinning of my hair is another issue but I use hair products to volumize my hair so it doesn't look bad once it is all styled. Also, since starting the AIs last year I gained 10 pounds which are almost impossible to lose. I was told the AIs slow your metabolism and that's the culprit. I cut back on food portions and trying to exercise on my treadmill and do weights for osteoporosis. My DEXA scan September 2025 showed osteopenia in my left hip for the first time.
I have read here that "everyone" responds differently to each AI. So I would suggest to give it a try.
Hopefully it will be the AI that you can stick with.
All the best to you!

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@briarrose Thank you for taking the time to share your experience. I wish you all the very best!