We started my wife at 5 mg, went to 10 mg, she had diarrhea and had to take an Imodium once a week, then she had nausea, and we went back to 5 mg, and finally stopped the Aricept. It did not seem to make any significant change in her memory. We started in late 2023, when she was first diagnosed with White Matter disease, and at high risk for Alzheimers, by blood test. We just stopped the Aricept last month and her nausea has abated. She refuses to go back to her Geriatrician, as she blames her for having her stopped driving. I'm not sure anything is going to change her back to the vivacious person she was. All of the medications seem to have annoying side effects, so we are just going along together now, into the sunset. She does have a caregiver, five days a week, and her Plan of Care is for 24/7. I am the 24/7 unpaid caregiver, and at some point in the not too distant future, I may have to go to the live in caregiver for her., as we are both 90, and I am not exactly a Spring Chicken. Thank goodness for our Long Term Care insurance! We are aging at home. Our kids are supportive, though most live quite a distance away, but for our daughter, who is an hour away. One day at a time.