I was on venlafaxine for about a year, for my bipolar/depression and here is my warning. If I missed a dose in the morning I was in the ER by the afternoon - non- stop violently sick (vomiting), a head-exploding migraine (worst ever) & dehydrated from the constant vomiting. After the 3rd time this happened, I begged to be taken off. And you have to be very slowly weaned off this med. That was my experience.