@hopeful33250 - mepolizumab (Nucala) is something I have to reorder monthly (they don't prescribe/dispense it in, say, in a 3-month supply). I keep it in our refrigerator (has to be kept there, but not much bigger than two decks of cards placed end to end), and I give myself the shot each month. It is an autopen, so you really don't see the needle at all - just this plastic thing. Easy to do. I've not noticed any side effects.

I was not big on being on prednisone, especially with only sleeping four hours nightly on it and having trouble blurting out things that I should really keep to myself to my family members. Not ideal for positivity and diplomacy, I guess.

The steroid rinse, which I've not yet used since it's not really cold and flu season, is budesonide. You mix it in a saline rinse bottle, which many people with allergies and asthma already have around and know how to use. You just add the nonrefrigerated liquid vial to the saline rinse bottle with the distilled water and saline, and then use it like a normal nasal rinse. My allergist just prescribed this to help stave off the very long-lasting colds and upper respiratory infections I seem to get every winter. So, here's to a better winter next year!

You do have to qualify for mepolizumab (Nucala), but it was not a problem for me to qualify. I had wanted to be on omalizumab (Xolair) for a long time, which my aunt in CA used and was lifechanging for her. She was certain I could talk my allergist into putting me on it. My allergist and I were both pretty sure it would indeed help me, but I never came close to qualifying. My IgE levels never hit the right number.

From my experience, I think it would be worth your while talking to your doctor about a biologic sooner rather than waiting till your appointment. You'd likely be in for a video chat or prerecorded video lesson on self-administration, but that should not be a big deal.