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Methotrexate

Polymyalgia Rheumatica (PMR) | Last Active: 4 hours ago | Replies (7)

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I have been on prednisone since end of March 2025 & added methotrexate end of May 2025. I’ve been lowering prednisone as suggested by rheumy & now at 2 mgs dropping very slowly.
Methotrexate I suppose it working? My pain levels are extremely low (yea!) except for maybe arthritis creeping up in shoulder? I’ll be 73 in a few weeks so a few old age related mild aches are extremely acceptable right now!!
Methotrexate does cause me fatigue a day or so after taking & I nap if I need to. Then I’m ok.
I see rheumy early next month & we’ll look at all the lab #s. I’d like to know when & how fast I can be weaned off methotrexate! I take 15 mg once a week. I don’t know what it’s doing to my internal body!

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Replies to "I have been on prednisone since end of March 2025 & added methotrexate end of May..."

@kare1 as well as the usual things, make sure they pay attention to the blood cell counts. Apparently some changes in ratio of white cell counts are expected, but from personal experience changes in the red blood cell counts can be more problematic.