@stonewheel

Have you seen the "bathtub theory" that explains how IL-6 inhibitors work. I found this "simplistic diagram" when I wanted to know how Actemra worked.
https://www.researchgate.net/figure/Mechanism-of-action-of-tocilizumab-in-RA-bathtub-theory_fig2_221967570
-------------------------------------
It took me months to understand this diagram. One day I realized the red "Y-shaped" thing in the lower right corner of the diagram was a molecule of Actemra which caused a drastic INCREASE in circulating IL-6 in the tub water which represented our bloodstream.

Then the magic occurred and the immune system resets and we are in remission ... clear as mud.

Hint: The IL-6 drain is the bottom of the tub not where the IL-6 molecule attaches. The receptor where Actemra attaches blocks the activation of the communication network that activates the immune system which cranks out too much IL-6. The communication network turns down our overactive immune system so the IL-6 faucet returns to normal. Over time ... the excess IL-6 is cleared out or is catabolized.

Artificial intelligence explains it this way:

The Bathtub Analogy

The Faucet:
Your body makes a protein called Interleukin-6 (IL-6). IL-6 is a messenger that tells your immune system to fight germs.

The Water:
In healthy bodies, the faucet runs at a normal rate. But in diseases like arthritis, the faucet runs too fast. It fills the bathtub with too much IL-6. This extra IL-6 causes the immune system to attack healthy tissues.

The Drain (Actemra):
Actemra is like opening the drain in the tub. It blocks the IL-6 from locking into your cells. This stops the "water" from overflowing, which reduces pain and swelling.