@lostinkc The instructions with Trikafta are to take it with an adequate amount of fat. Frankly, I've never had any success pinning down someone on exactly how many grams of fat are needed at a minimum. The important thing is to take your Trikafta with a fat-containing snack or meal, and personally I try to get at least 9-10 grams or more ... a handful of nuts, or a fat-containing protein bar, or an egg and buttered toast, etc.