@colleenyoung I’m 68 and like others here I have gone through years of testing and 3 positive sweat chloride tests. My genetics don’t really make sense, but I think that’s because we don’t entirely understand how genes can affect us and what some sequences mean. I have mutations that shouldn’t line up, but that’s what seems to be happening. I also have a somewhat rare sequence of MTHFR that leaves me more open to epigenetics so maybe that’s what happened. CF Foundation mentions genetic nonsense (I think that’s the term they used) and I think that is an indicator that we are still in the infancy of genetics/ metabolics and environmental affects. It’s fascinating so far and that makes it less scary for me. Thanks for being here!