I am wife of high risk patient and my husband is on the same 2 drugs.

He is 70 years old and I did not notice any changes in him (so far, he is about 2 months on Orgovyx and about a month of Nubeqa). He does not even have hot flashes 🧿, &knock the wood. He still works full time and also has some "gigs" on the side and his job is keeping him very active and engaged. I did not notice any changes in energy level either and he is exercising every day too.

He does not like to think about cancer in general, so I think it is very helpful. I often ask him how is he doing and he always looks at me with surprise and says ; "I feel great - why ??? What did you read now ?" 😋 Like I maybe read something and am now checking if he is OK lol , he is so funny in that way lol.

Saying all of that, it is a well known fact that ADT effects mood and energy level and it can go from "no effect" to "major depression" effect and all levels in between. It seems that your husband is really very little effected , so little that only you can sense those subtle changes and maybe it could be of comfort to you 💗. Maybe the fact that he has aggressive cancer and that he has to deal with all this is effecting his mood more than ADT ? : ((( It is really much to deal with even without ADT : (((. I am not on ADT but I definitely changed since my husband was diagnosed 🥺. I am more subdued, have zero patience with people outside my immediate family, nothing is "like before" in my mind and my energy level is much less since so much energy goes to dealing with emotions of all kinds .