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What if this prevents cancer from becoming resistant?

Prostate Cancer | Last Active: 4 hours ago | Replies (56)
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@northoftheborder

So the main question is: can the PSA level tell us how many bad cells there are or not? These cells seem to be hiding/going dormant.

I've seen guys whose PSA levels dropped to 0 and then progressed. I've seen guys who had prostatectomy and died within a year. Of course, I'm talking about stage 4 and advanced cases.

I don't think there are other factors, if you will—an individual cancer profile and the body's individuality.

And I'll be honest, I'm scared. Erleada and ADT suppress the cancer, but I'm shaking like a slender aspen.

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northoftheborder | @northoftheborder | 4 hours ago

@denis76 No, PSA tells whether (non neuroendocrine) prostate cancer cells are active/awake.

MDT, PDRT, chemotherapy, radioligands, etc, kill prostate cancer cells. ADT encourages any survivors to go dormant. And ARSIs like the lutamides delay or prevent dormant cells from waking up by essentially pulling the blackout curtain shut.

In the recent past, when they'd treat metastasic prostate cancer with just ADT, there were a lot more cells still available to "wake up," and without ARSIs, the curtain was wide open for the sun to shine in, so it's not surprising that the old conventional wisdom was that hormone treatment would usually fail within 18 to 24 months (as they told me in 2021).

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