@rmbrandt Duloxetine is an SNRI antidepressant. It works on the serotonin and nor-epinephrine producers in the brain and inhibits them from working which (in theory) causes the brain to produce more of these chemicals. Duloxetine is used for depression, anxiety, and nerve pain. I take 30 mg a day for depression and pain. I also take Gabapentin 300 mg. Oxy is an opiate. It is used strictly for pain management. I can tell you from experience (as a recovering addict) that oxy is hard to get off of. Having said that, if you need it for pain, then use it. Pain management is different than using it recreationally. The reason your doctor is opposed to it is probably due to the addictive factor. Also, our bodies get a tolerance to opiates and people end up needing more and higher doses over time. I hope this helps and I am sorry that you are going through all of this.