← Return to Stage 4 Metastatic - what to expect after 6 months?

Discussion
prbutler avatar

Stage 4 Metastatic - what to expect after 6 months?

Prostate Cancer | Last Active: 13 hours ago | Replies (65)

Comment receiving replies
Profile picture for kitlund @kitlund

Are there any other octogenarians out there?
At 82, I have finally come to grips with my prostate cancer. Early on (65ish), my GP watched as my PSA began to inch upward at about 1-2 points per year. When it hit 16, I learned about the 4K test, took it, and was told that I had only 10% chance of ever having problematic or metastatic cancer.
I liked those odds, shared them with my GP, and he suggested that we would "watch and wait."
Then, almost to the day I turned 80, I began to experience nocturia (get-ups, poor stream, double voids, etc.). I endured this new reality for several months until it became rather uncomfortable, but reminded myself that I was, after all, in my 80s now . Consulting the internet assiduously (I'm a retired academic), I figured I had to become reconciled to the BPH that 80-90% of ALL octogenarians experience. But I decided to consult a urologist anyway. He put me on Alfuzosin, which cut my nocturnal wakeups in half, thankfully. But he suggested that we do a few more procedures, given my nocturia and my extreme fatigue.
Well, after the MRI, the biopsy, the PET Scan, (and a newly measured PSA of 30--apparently LOW for this group), my urologist told me that I had an aggressive stage 4 prostate cancer. A medical oncologist put me on bicalutamide for a month, prior to the Orgovyx, which I have now been taking for a month.
The plan is to continue with Orgovyx for another month or so, and then consider radiation. The possibility of a HoLEP procedure looms...but, of course, pre-radiation.
My question is: will the HoLEP substantially mitigate my nocturia (which is a manageable 2-3 getups, giving me three 2.5 hour "naps")? Or should I just continue the Orgovyx (PSA now down to 4.2, two months into my ADT) until I reach my PSA nadir and then do the radiation?
Any suggestions or sharing are much appreciated.

Jump to this post


Replies to "Are there any other octogenarians out there? At 82, I have finally come to grips with..."

@kitlund What did the Radiation Oncologist say about the size of your prostate and ability to perform radiation? If too large you may need a procedure to reduce it. During radiation urinary symptoms usually get worse, but a few weeks after radiation the inflammation will clear. At that time urinary performance is usually improved from the pre-radiation condition.

@kitlund
Orgovyx can be pretty hard on someone 80+. Due to your BPH, I wonder if your prostate is over around 75 cc. During one of the monthly meetings the Mayo radiation oncologist said that he didn’t like to radiate a prostate over 75 cc. Hopefully Orgovyx can bring it down So they can do radiation. Maybe the HoLEP can reduced it enough.

Once you’ve had radiation getting off Orgovyx Would be a good idea since it can cause a lot of side effects and fatigue can be difficult for many people. I know and a lot of guys in their 80s that are on Nubeqa alone. It works really well to keep the PSA down and prevents the testosterone from helping the cancer grow. Something to discuss with your doctor.

I was having a problem getting up too many times at night, I’d wake up and feel like I had to go and I knew damn well I didn’t. I’m now taking Myrbetriq And I usually don’t get up at all at night anymore. I’ll be laying in bed reading after I wake up and maybe wait a half hour or 45 minutes before I get up go pee. No urgency any more. Gemtesa is supposed to work similarly. My urologist was real helpful when I asked about getting one of the drugs.