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I developed Crohn’s disease in 2023, at the age of 55, following a brutal bout of Covid that had be bedridden for a month and still unwell for another. I started Skyrizi early 2024, and after 6 months or so my Crohn’s symptoms receded. About a year and later I was diagnosed with mild bilateral bronchiectasis, following 2 horrific months of respiratory illnesses with severe coughing.

The most common side effect of Skyrizi is respiratory infections. If I discontinue it, my Crohn’s symptoms will return and they are severe and dangerous. So now I mask indoors, don’t travel on planes or other public transport, and mostly live like a hermit. I also nebulize 7% saline daily and am grateful my bronchiectasis is “mild” and without complications (MAC/NTM).

I have read that some bronchiectasis is caused by autoimmune disorders, which seems likely in my case. Some even think it can be an extra-intestinal manifestation of Crohn’s.

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Replies to "I developed Crohn’s disease in 2023, at the age of 55, following a brutal bout of..."

@bronchiectasaurus Hello! Has your GI dr mentioned the crohns biologics that are "gut-selective" meaning they have fewer systemic effects? When I went through this spring with multiple infections my GI guy's first suggestion was to switch from Humira, which has major systemic impact, to Entyvio, which targets the gut. (I am right now off biologics altogether, so far without relapse).
I don't know what the risks would be, of course, in your situation which I can see is challenging.
(Are you able to see an IBD specialist? I have been fortunate to be taken care of at the NYU IBD Center in NYC for many years, they are among the best. Like bronchiectasis, many all-purpose gastroenterologists are less up on the IBD field, which is changing rapidly.)