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Nearing end of Evenity treatment
Osteoporosis & Bone Health | Last Active: Jul 11 11:01am | Replies (27)Comment receiving replies
Hi Michael, i'm curious about your progress on Prolia after Evenity - have you seen further BMD gains? The romosozumab to denosumab sequence is well supported for maximizing BMD gains, and some here are using this approach (1-2 yr Prolia after Evenity). Your experience is interesting to follow.
You mentioned planning to stay on prolia for at least 10yrs - do you and your doctor have a specific exit plan? Have you come across any new strategies for transitioning off long-term Prolia?
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Hi @mayblin - I'm progressing in the spine with Prolia after Evenity but just holding on in the femoral neck area and hip. Attached shows my progress up to my last DXA in December.
As for the Prolia exit plan, I'm not too sure. If the new AGA2118 drug does as well as I think it's going to do, and it gets approved in the next 5 years, perhaps that could be an offramp from Prolia without losing bone density. But until it passes and has some real world testing done, I will wait out on Prolia until I reach about ~1.7 in the femoral neck, which might not even be possible.
There seems to be a lot of activity happening on doctors trying to figure out the best way off Prolia and my guess it will be a combination of early Reclast plus Evenity. Trails happening now.