@diverdown1 Thank you so much for your heartfelt reply and the links to those studies. I so understand how you feel, and I have had very much the same situation. I never really know how I am going to feel. I've spent decades taking care of myself, eating right, not drinking, getting plenty of exercise, including weight training, yoga etc.. I often feel as though my body has been taken over by an unseen undetectable force (I know it sounds crazy but the symptoms are nuts). I get acupuncture which always helps me feel at least slightly better for even a few hours. My latest issue is tooth sensitivity. I have been to the dentist and he finds no reason as all why my front lower teeth should be sensitive. It comes and goes.. along with a psoriasis patch on my back, joint pain, extreme bloating, bloodshot eyes, the fatigue from hell etc. My younger daughter lived with me when i (we ) got covid and she pointed out I have never been the same. The GLP-1 I started last week was a miracle. I felt amazing for a few days, but then it starts to wear off.. the important thing is as you said, this is inflammation which the GLP tamps down and then I feel like myself. I am longing to have my life back, to feel like I have some control over how I feel. The fear around eating something that will create a "flare" is not healthy, so I avoid social situations, and making any real plans because if I feel whatever this is I'm almost unable to function. Last time I traveled, all I could think about was when do I get to lay down.. this is not ok. And the medical community has failed me so many times, as is the case with so many other people. I'm sincerely grateful for the response and support. It's been a lonely 4 years..