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Have MCI, sharing new intel re Lithium Orotate
Early Dementia & Mild Cognitive Impairment (MCI) | Last Active: 2 hours ago | Replies (131)Comment receiving replies
@plus
As for timing of the dosage, there is a recent editorial by Tomas Hajek.
https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/lithium-orotate-distinct-compound-or-simply-li-after-administration/52E4CFC3727F480DF94FBE4E93BFA7BD
He states that because the human stomach is much more acidic than a mouse stomach, LiO would be separated in the human stomach and so the special properties of LiO would not reach the brain, only the Lithium ion. It would be no different than taking LiC. He does say that taking it *after a meal* would probably let more LiO travel to the brain.
Of course, more experiments are needed.
Replies to "@plus As for timing of the dosage, there is a recent editorial by Tomas Hajek. https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/lithium-orotate-distinct-compound-or-simply-li-after-administration/52E4CFC3727F480DF94FBE4E93BFA7BD..."
@nb14
I see it as a low-cost, no-risk adjustment. If there’s any chance that a less acidic gastric environment preserves more intact LiO and allows the orotate carrier to do whatever it does in terms of amyloid evasion, taking it after a meal is worth doing. I already take it in the morning because i take Magnesium L-Threonate in the evening and those two compete. So I just need to be sure i eat my yogurt first before my normal morning meds.
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@nb14 "... *after a meal* would probably let more LiO travel to the brain."
Thanks! Today's our first trial of that, and we're slightly worse w/in daily variation so we'll continue and monitor for a few days. We've also been on morning & night Famotidine for reflux for years, and today we stopped taking it with the LiO so maybe it had been helping.
Plenty of variables to consider!