← Return to Have MCI, sharing new intel re Lithium Orotate

Discussion
Comment receiving replies
Profile picture for pb50 @pb50

@plus I realize we are all wandering through the desert of resources hoping to find a productive path. But now that you and your LO seem to be in a positive place, I strongly encourage you to hold steady on dosage.

I cannot imagine that (a) there is a prescription that could be written for LiO. As far as I am aware the OTC mineral supplement Form is all there is. My guess is that best case you may get a ”let me know how that works out” from your Doc- and More likely you will get “let’s Wait For human trials” - which are seeking philanthropic funding since no pharmaceutical entity can monetize it - so-big pharma is out. Plus they are already in the game with the two approved drugs in trial now.

I encourage you to dive into understanding how LiO affects available lithium getting to the brain by avoiding sequestration within the amyloid plaques. And then how the trash amyloid plaque and tau must be removed - flushed out - and that Glymphatic process only occurs during slow wave non-REM sleep.

So there are a lot of moving parts in this process. LiO seems to facilitate some but not all of them. So i personally am working daily to achieve 12-15% slow wave sleep (SWS) that is not REM by using an apple watch and an app that is pretty consistent in how it classifies sleep stages.

My point is rather than trying to find the optimal dosage early, find one that isn't problematic - recognizing that less is more - and work on the other requisites to rid the brain of amyloid and tau proteins. It is all necessary to produce results.

Jump to this post


Replies to "@plus I realize we are all wandering through the desert of resources hoping to find a..."

@pb50 "...encourage you to hold steady on dosage." Thanks for that and all your contributions on this topic - including starting it!

"...amyloid plaque and tau must be removed - flushed out - and that Glymphatic process..." Yes! I keep thinking each day will be the one with enough easing of chaos to delve into that whole topic further. Maybe tomorrow...

"...a lot of moving parts in this process." Absolutely!! "...working daily to achieve 12-15% slow wave sleep..." Hope you can scrape together the cash for the ring to help with that, and report back on if/how it helps.

"...rather than trying to find the optimal dosage early, find one that isn't problematic" None have been, so far. Sometimes high dose has worked notably better, other times (eg. 4.8mg) worse. This is one of the reasons I'm favoring high dose at this few weeks into the LiO. As for "...less is more" I'm not sure that's the case, given we're not modified mice w/all the other biological differences - plus the unregulated nature of OTC supplements. My impression is you're saying too much LiO if effective, could poison the brain with uncollected debris. My hope is that our efforts to reduce nocturia while increasing daytime hydration can help. Sleep monitoring probably wouldn't hurt, but we already know better sleep is probably good and we're working at it.

Again, thank you for your kind and helpful contributions here, taking the time to offer your informed perspective, and your patience with my slow experimental learning curve.