@californiazebra I'm glad you no longer need the Kisqali and hope you'll avoid problems with the letrozole. My first afib episode was in August 2023 before my breast cancer diagnosis in the fall of 2024. Now I wonder if the afib was an indicator that I had cancer before the mammograms and other tests indicated it. The reason I say that is I had no risk factors for afib. My cardiologists (I saw a couple) asked if I had cancer since it was a risk factor for afib so perhaps the cancer triggered the afib. At the time when I saw these docs, I said no because I did not know I had cancer then. I had the impression it was the cancer itself, and not any medication treating it, that could be a cause. One of those mysteries of cause and effect we never answer.

My afib was episodic and I was prescribed Eliquis. I was on the fence about taking it but when I had a couple more afib episodes decided it was the safe thing to do. I also consulted with 2 electrophysiologists who both said I was a candidate for an ablation. I had planned to do the ablation in the fall of 2024 but when the breast cancer diagnosis was made late in 2024, the surgery was cancelled.

After completing a double mastectomy and chemotherapy in the spring of 2025, I asked my electrophysiologist if I was still a candidate for an ablation. He said yes. Although my cardiologist says I need to stay on the Eliquis regardless of an ablation (my age 76 and being female are risk factors), I elected to have the ablation. My electrophysiologist says I could go off the Eliquis with careful monitoring for afib. I feel the ablation is one potential thing to protect myself. Plus, research now indicators ablation should be considered a primary tool to treat afib rather than a backup if meds don't work.

I have had no afib episodes since my ablation in September 2025 but remain on the Eliquis too.

I'm happy that your afib episodes have decreased so much since dropping the Kisqali. I would encourage you to get at least 2 opinions about an ablation. It's also possible that your afib episodes will continue to decrease even more then longer you go without being on Kisqali. It's possible they may disappear completely! That is my sincere hope for you!