@jum13 That is a very interesting thought...disturbing, too. I, too, have had P.N. for about 25 years and have been taking Pregabalin (Lyrica) for about 4 1/2 years, having briefly tried the Gabapentin (but had side effects right away). This was after about 4 years of spinal injections for pain and then back surgery. As of the last few months I've had increasingly difficult problems with mobility, much as you describe. I appreciate your post - it raises a legitimate concern. If you find an answer, please do keep us posted. Like you said, the medication does help -- a lot, for me. I've not been able to cut back without excruciating pain. Blessings to you, Barb