← Return to Anyone use SAMe (S-adenosyl-L-methionine) supplement for low mood?

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Profile picture for Lisa Lucier, Moderator @lisalucier

Hi, @equanimous,

I thought this article might be useful for you as you explore SAMe:

SAMe https://www.mayoclinic.org/drugs-supplements-same/art-20364924

Please note it says SAMe is generally safe, though it does mention the following related to its use for depression:

What the research says
Research on SAMe use for specific conditions shows:

Depression. While research has shown that SAMe has a positive effect in treating depression, most studies weren't well designed and included a small number of people.

Wondering what your doctor's thoughts are on use of SAMe? Have you tried prescription mood management medications in the past? If so, how did that go for you?

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Replies to "Hi, @equanimous, I thought this article might be useful for you as you explore SAMe: SAMe..."

@lisalucier Thanks, Lisa. I have already read the information. But, since the symptoms are new to me, I thought about it and felt exploring SAMe might be a part of the figuring it out.
After learning about the B12 deficiency possibility, I starting taking it and I actually feel much better! I think I will take a holiday from the SAMe and when I start again I will take it every other day.