@jenniebc Since you still have to clear your throat a lot, while taking that high amount of esomoprazole, it's worth seeing if you can make a change. Look at the other comments about tapering off very slowly and switching to famotidine. I had a similar situation where I was taking 20 mg Nexium in the AM and famotidine at night and still didn't feel good, so I tapered off, switched to famotidine, and then felt better than previously, and now just take Gaviscon (Advance) with alginate, or famotidine at night when I feel I need it. (and sleep on a wedge, eat early, watch diet, etc) Probably worth checking with doctor as well.