← Return to Have MCI, sharing new intel re Lithium Orotate

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Profile picture for pb50 @pb50

I have read that with interest. The neuropsychologist told me that my cognitive impairment as revealed in her 3 hour test batteries was barely “mild” impairment . And yet my blood markers as described in ATN test and newer pTau217 test suggests a large amount of amyloid and Tau proteins on board and suggest a diagnostic indication of Alzheimer’s.

I am going off LiO until we see the dosage Yankner et al target for their trial. Not because I think 10mg is dangerous but because i am experiencing sleep disruption and want to try and identify what may be contributing to it. I need to have my slow wave non-REM sleep reach at least 15% of total sleep for the Glymphatic process clean up any debris overnight.

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Replies to "I have read that with interest. The neuropsychologist told me that my cognitive impairment as revealed..."

@pb50
You sound discouraged.
You should be encouraged.

My understanding is that the ptau-217 tests show results decades before the symptoms occur. It, and amyloid beta, build very slowly. The best time to address it is before you have symptoms.

Shielding the Brain From Alzheimer’s | Psychology Today
https://www.psychologytoday.com/us/blog/the-breakthrough-depression-solution/202602/shielding-the-brain-from-alzheimers
The author has written several books on lithium and recommends lithium for his patients and in paid seminars. He is highly biased, but maybe his bias is justified.

My overly simplistic understanding of the brain cleaning process is that microglia, which need lithium, bag up the trash (autophagy) and the glymphatic system takes it out. So both are needed.