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How long can you be on Xtandi?
Prostate Cancer | Last Active: 5 days ago | Replies (19)Comment receiving replies
@jeffmarc That's good news -- it will be interesting to see the results when ARACOG is complete (it has just finished enrolling participants).
https://clinicaltrials.gov/study/NCT04335682
Note that it will be a head-to-head only against Enzalutamide (not Apalutamide), based on reported symptoms, and that it will be open label (so the participants and their doctors will know which one they're getting).
As for now, all we know is that Darolutamide didn't seem to pass the blood-brain barrier in mice in early tests. The impact on humans remains hypothetical, though ARACOG should add more certainty.
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@northoftheborder
During the intro from PCF, they specifically said that Darolutamide doesn’t pass the blood brain barrier. The test results they had, already showed that Darolutamide caused fewer brain issues. Sort of interesting they mentioned getting lost in a parking lot they were familiar with. I’ve never even faintly felt that problem. My wife has that problem and she’s not on any drugs.
Another interesting thing. Many people switched from Enzalutamide to Darolutamide, But no one switched the other way.