There may already be a topic on "Nocturia" here that I've not yet seen, but I'll mention something related to prior references here to the likely importance of sleep in clearing plaques.

Sleep interrupted by visiting the bathroom during the night can be a problem, as others our age may have noticed. We years ago stopped liquids 4 hours before bed, but it didn't help much. I bought an inexpensive "analog" TENS box and rechargeable 9v batteries for it. We started with the two electrode pads at various places on the Tibial nerve and enjoyed immediate improvement from typically 6 or more nightly sleep interruptions, to 3 or 4 and sometimes fewer.

A year or so ago I found reference to Sacral pad placement, and immediately got to 1-3 nightly sleep interruptions. Sometimes none at all. We also noticed a reduction in daytime urgency.

Again, I mention all this here in the hope it may help others dealing with MCI to get better sleep. Hopefully it could be helpful even for those not taking LiO, but if LiO does prove to support healing during deep sleep all the better.