@jeffmarc wrote "Surgery is recommended as the best treatment for large cribriform."

This is no longer unconditionally accurate given the results of the studies I cite in my prior comment. For men with >=GG3 and/or >=pT3b cancer, the weight may now be shifting in favor of radiation + ADT over surgery as a first-line treatment, given what the PROTECT trial showed in terms of lower incidence of later metastasis. There won't be a clear-cut answer without additional studies, of course.

There can be other considerations too and every man should work closely with his team of doctors. But this does show how quickly our understanding of prostate cancer treatment can sometimes evolve.