My husband lost weight starting with the first time he got chemo. He lost a total of 35 pounds and seemed unable to put on weight even after he stopped chemo. He ate a lot and yet still seemed to drop weight. It was discouraging to go for an appointment and see that he had lost more weight in spite of an increase in his food intake. His oncologist changed the Creon dosage to 36,000 units which definitely seemed to help. We also focused on the three meals and two snacks a day and being certain he didn't skip meals or snacks even if he didn't feel like eating. When he went to his appointment the end of May, he weighed 151. Last Friday he weighed 158. I think exercise is also very important. Don't know if your husband is exercising, but if not, I would definitely suggest he start. I think walking helps with appetite as well as making you feel better. Hope your husband will show imprevement soon. My husband was quite discouraged with the loss of weight, but persevered and now is making great progress.