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How long can you be on Xtandi?
Prostate Cancer | Last Active: 5 days ago | Replies (19)Comment receiving replies
@northoftheborder
At yesterday’s PCF online meeting about the ASCO Conference they discussed the difference between Darolutamide and Enzalutamide When it comes to brain fog. Darolutamide was much better and that also applies to apalutamide They specifically brought up the fact that Darolutamide doesn’t pass the blood brain barrier like the other two drugs. It’s a study called ARACOG. Here is a slide from that talk.
Replies to "@northoftheborder At yesterday’s PCF online meeting about the ASCO Conference they discussed the difference between Darolutamide..."
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@jeffmarc That's good news -- it will be interesting to see the results when ARACOG is complete (it has just finished enrolling participants).
https://clinicaltrials.gov/study/NCT04335682
Note that it will be a head-to-head only against Enzalutamide (not Apalutamide), based on reported symptoms, and that it will be open label (so the participants and their doctors will know which one they're getting).
As for now, all we know is that Darolutamide didn't seem to pass the blood-brain barrier in mice in early tests. The impact on humans remains hypothetical, though ARACOG should add more certainty.