@djfone Was your husband evaluated for Exocrine Pancreas Insufficiency by taking the Fecal Elastase-1 test. This test determines if the pancreas is producing sufficient digestive enzymes. There is often impairment due to the primary tumor interfering with the production and secretion of digestive enzymes. An insufficiency results in malabsorption and weight loss despite increasing the consumption of calories and this promotes loss of muscle mass.

EPI is treated by Pancreatic Enzymes Replacement Therapy (PERT) using Rx Creon, Zenpep or other brand. Unless a pancrealipase is prescribed to address EPI, one can consume an inordinate amount of protein shakes and carbohydrates and barely keep up in trying to maintain weight. Enzymes supplementation is the key in resolving the weight loss.