I've been on Tagrisso for 8 months now. I'm putting my faith on it to keep me the cancer from returning. So far I've only had minor side effects that are very tolerable . Mostly dry nails and some hair thinning. This forum is great at collecting data from other Tagrisso users. I've read a wide range of experiences. One thing I know its important to drink plenty of water through the day. It seems I have less S/E when I do. Moisturize skin a lot. When my nails are brittle, I wear gloves when washing dishes . Good luck on your treatment. Meditation and exercise to keep your body and mind strong.