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Forgot to take my pills this morning
Polymyalgia Rheumatica (PMR) | Last Active: Jul 19 6:14pm | Replies (17)Comment receiving replies
Thank for everyone's replies. <3
Update: As you've suggeted, I'm pretty sure that All-Over High-Grade Ache with Shoulder Feature (TM) was the PMR resurfacing. It started to go away 2 hours post prednisone and is now gone. I never expected anything like that just because I was six hours late taking my dose. I know the half-life of prednisone is only four hours, but still, zero to 60 in six hours was quite something to experience.
This episode paints in stark relief exactly what the PMR pain is and where it is. As I've reported elsewhere, I have a couple of other leg issues that complicate my mobility. I've never really thought that the PMR affected my Lower Kinetic Chain (as the medical gurus call it) so much. But going on Prednisone and feeling an immense improvement, and now having this self-induced flare have convinced me that from hips to ankles, I've been affected.
I do have a pillbox / med minder, but for some inexplicable reason I had not added the P to my other daily morning pills. I now have done so.
Replies to "Thank for everyone's replies. <3 Update: As you've suggeted, I'm pretty sure that All-Over High-Grade Ache..."
@p0rtia If the half life is four hours and you had not taken a dose for 30 hours (since your dose the day before) that is 7+ half lives. Enough time for you to have no measurable prednisone in your system. Thus the pain returned.
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@p0rtia
Some people say a "new batch of inflammation" happens every night. That might be true but the timing coincides with the approximate time when an a.m. dose of Prednisone wears off in the middle of the night because of its half life.
Some people metabolize Prednisone slower than other people. The lucky people who metabolize Prednisone slower might be able to get a full 24 hours of pain relief from a single morning dose of Prednisone but some people don't get 24 hours of pain relief. Prednisone has a rapid onset and short half-life, clearing your system in roughly 16 to 22 hours. Fortunately the rapid onset of prednisone is a quick fix for the problem of increasing inflammation levels whenever it happens.
As you probably have learned the inflammation comes back as soon as prednisone is eliminated from the body. The circadian rhythm is a characteristic of cortisol from the adrenals in the body and not a characteristic of oral Prednisone.