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Greeting to all on this tough PMR/drug journey. So thankful to learn ( in a post here) about https://prednisonepharmacist.com/ . Her videos answer a lot, even what questions to ask your doctors. I learned that between 2 am - 6 am is a normal time for inflammation and that is why I wake up with severe shoulder pain. Dr. Megan's answer is to take 1/2 your prednisone dosage at night and one in the middle of the night. THIS HAS HELPED SO MUCH! I'm going to share this with my rheumatologist in hopes that she share it with other patients. God bless.

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Replies to "Greeting to all on this tough PMR/drug journey. So thankful to learn ( in a post..."

@sfink I hope you realize that the nighttime dosing is contrary to the approach used to take your dose in the morning in an effort to mimic your adrenal glands release of cortisol. This works to keep your circadian rhythm consistent.
My Rheumy always says every patient is different. Glad it works for you.
I know I would not do well on a nighttime dosing schedule because even small prednisone doses taken in the morning can disrupt my nighttime sleep.