Just finished 18 months of Orgovyx this week. I had all the side effects listed on the Orgovyx.com site such as fatigue (extreme), weight gain, ED, loss of libido, hot flashes, diarrhea and one they didn't list: loss of neck-down body hair. They don't call it chemotherapy but it must be a close cousin. I hope by fall to be clear of most of these. It did excellent work on the cancer: PSA <.01 for the last year.