I did 6 months of Orgovyx and my T was up to 250 2 months after treatment. It comes back quickly. I started feeling better 3 weeks after treatment. I was one of the fortunate ones and didn't have hot flashes. I had a bad case of Radiation Proctitis and got cauterized and used Mesalamine for 3 months to stop the bowel inflammation. At 15 months it seems my bleeding, gas and urgency is abating. I found the urgency and rank paint peeling gas the worse part of the whole thing and had to be strategic about eating and bathrooms. It has been a long time since I could trust a fart and glad to say I pretty much can at 15 months. Imodium helped and would use it on days that I had places to go and things to do. It isn't suggested to use it every day long term. Hope this helps.