@blashatw As far as medications, my primary, and the only prescribed medication (for my lung stuff), is Trikafta. In addition to that I take a prophylactic 250mg dose of Azithromycin three times a week. In spite of that, I do get periodic infections -- most often Achromobacter -- and for the most recent one, my CF doctor put me on a course of Bactrim. For more serious infections (I had one a few months ago), I was on round-the-clock IV treats with a stronger antibiotic. That was a VERY hard thing to endure; my wife had to administer the IV treatments and neither of us got very much sleep for 10 days. At the end of that time, I was also in distress because of fluid retention and had to go to the ER. Don't want to do that again, but I'm sure I will ...comes with the territory. I will say, however, that my exacerbations are much less frequent since my CF diagnosis when I was put on Trikafta.