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The Role of Repurposed Drugs in Prostate Cancer Therapy
Prostate Cancer | Last Active: 8 hours ago | Replies (30)Comment receiving replies
Ran across this today and found it very interesting.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11595001/
Replies to "Ran across this today and found it very interesting. https://pmc.ncbi.nlm.nih.gov/articles/PMC11595001/#sec2-ijms-25-12441"
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@doyourresearch
WOW !
GREAT FIND @doyourresearch 🙌 !!!
"Two antihypertensive medications are in Phase II trials for prostate cancer: carvedilol and propranolol. Carvedilol is assessed before surgery, while propranolol is examined preoperatively alone or with etodolac. A retrospective study shows that long-term atenolol use significantly reduces prostate cancer risk by over 50% .
In vitro and in vivo studies show that captopril and candesartan inhibit prostate cancer cells despite not undergoing clinical trials. Captopril increases p53 expression, inducing apoptosis in prostate cancer cells, while candesartan reduces tumor growth and angiogenesis by inhibiting VEGF expression. Hydralazine induces demethylation in prostate cancer cells, re-expressing suppressed genes "