← Return to Dental work while taking Tymlos?

Discussion
shocknot26 avatar

Dental work while taking Tymlos?

Osteoporosis & Bone Health | Last Active: 3 hours ago | Replies (75)

Comment receiving replies
Profile picture for gently @gently

ipg,
I see luck in being trapped between the two very best osteoporosis medications.
Rats given the equivalent of the 20mcg dose in Forteo were treated for 70% of their lifetime without developing bone tumors. https://journals.sagepub.com/doi/pdf/10.1080/01926230490462138
Evista slows down bone resorption. It is said to be equal to alendronate, except that it doesn't seem to protect the hips.
There is a lot of hope for new medications, and it is reasonable to think about buying time. as long as you don't risk fracture meanwhile. It's good that you are examining and questioning everything.
Forteo gives your bloodstream an intense jolt of part of the parathyroid hormone. The half life is about 1 hour but it is gone from your bloodstream within about 4 hours. So these poor rats were inbred to lead to an identical line of rats and they upset trials for 50 years (not just in osteoporosis trials, because they lack the genetic diversity to prevent spontaneous tumors. The tumors didn't happen in response to exposure to teriparatide.
I think bisphosphonates are the only osteoporosis drugs that give you a holiday. With Evenity, Forteo, Tymlos you lose the increase in BMD usually in close to a year. With Prolia you lose more than the increase and most people fracture within the first year.
The trouble with Forteo and Tymlos is that they can stop being effective at around 18 month.
If anything make you wonder, I hope you ask. I'm enjoying our exchange.

Jump to this post


Replies to "ipg, I see luck in being trapped between the two very best osteoporosis medications. Rats given..."

@gently
First, I commend you from your extensive research. Do you have a medical background? I guess my concerns are based on longevity, MRONJ and side effects. That’s everyone’s concerns. Do you anticipate being on medication for the rest of your life? My friend is considering Reclast- 3 yearly and done. The dental concerns I know will interfere with the Drs. I am now do for a dexi. 2 years ago it was -2.9. I am choosing to wait a little longer just so I can check on my other medical conditions and make sure I have nothing else that I must treat first. Early 2027. Someone wrote in she didn’t want 1 dexi to determine medical treatment. My dr says “just don’t fall”. I’m as careful as I can be . I was in aqua pt yesterday followed by an exercise class. On my weigh to a trainer. Do you use any of the Fortibone products? You have been very helpful. I’ll be 70. Your age??