Two years taking Anastrozole - age 73 taking this AI for return of breast cancer after 20 years after surgery and radiation. I declined chemo due to my age. I was also concerned about hair loss but maybe just a little extra shedding but no major loss. Biggest issues sleep disruption, vagina dryness and overall joint soreness that during my first year was managed with exercise - this 2nd year had my oncologist prescribe acupuncture = had my first treatment and after a little extra pain after treatment subsided and feeling fantastic - after pain is not usual since getting extra blood flood to areas for healing. Also helping with my sleep. The vagina dryness was resolved with the estrogen ring which is a god sent. Talk to your oncologist about how long you need to remain on a AI - overall reports of heart disease, dementia. bone breakage issues - our bodies need estrogen for our overall health - I had a friend that stayed on this AI for over 7 years and she came down with heart disease. Talk to your oncologist about limiting the time on the AI - managing your overall health with regular check ups to be proactive and prevent "other health issues". Good luck!