@jdcook That is a very good question, the short answer is "You CAN, but it is not a good idea." Those were the words of my ID doc, echoed by my primary, when I was being treated for Pseudomonas and MAC.
Let's begin by saying that all three antibiotics and alcohol are metabolized by the liver. First think about how hard your liver must work to handle alcohol, or one antibiotic, then consider how much harder it works to handle all four at once. There are studies showing alcohol use while under antibiotic treatment increases the risk of permanent
liver damage.
Second, ethambutol plus alcohol specifically increases risk of dizziness.
Finally, your body is fighting an infection, which is taxing to all your systems and organs. Adding alcohol just makes your liver work harder.
What did I do? Gave up alcohol while on the antibiotics, except, with the agreement of my docs, I took two weeklong "antibiotic holidays" during my treatment, and allowed myself one alcoholic beverage every day or two during it. It was great for my mental health to feel less ill for a few days (Ihad a lot of fatigue and digestive issues), and to be able to celebrate some very special events with friends and family.
It is best to consult with your care team, especially if you have other health issues, or already have lab or clinical evidence of liver or kidney issues. Have you asked your doctors for their opinions?