@peggydobbs this one is a bit tricky. The reason I take with food is because the prescription says to take “after a meal”. This usually means the drug is fat soluble. Which means not absorbed well without food. HOWEVER if you read the research, there is negligible difference in amount absorbed with or without fat. One said take with high fat meal for best absorption but in the same article said to not take with high fat because it can increase dose amount. So back to the primary reason for us is to prevent stomach upset. I eat low fat (high protein) anyway so I take after food to prevent any stomach upset.