@reesew07, you are in good hands at Mayo Clinic. If I am understanding correctly, you have symptoms that suggest you may have mast cell activation syndrome (MCAS), but the diagnosis has not yet been confirmed. Do I have that right?

"Diagnosing MCAS, which affects each patient uniquely, relies on a combination of the major and two minor diagnostic criteria set forth by the World Health Organization. ... Due to the lack of access to or limitations of traditional diagnostic approaches, affected patients often experience lengthy diagnostic odysseys." https://news.mayocliniclabs.com/immunology/mast-cell-activation-syndrome/

This article explains more about Mayo Clinic's "random urine test panel can also be used as an adjunct diagnostic test in scenarios where acute and baseline serum tryptase measurements cannot be readily attained."
- A simpler path to answers for patients with mast cell activation syndrome https://news.mayocliniclabs.com/2025/08/11/a-simpler-path-to-answers-for-patients-with-mast-cell-activation-syndrome/

I'm glad that you were able to get an appointment at Mayo Clinic so that they can help either confirm or rule out MCAS and help you find answers.

Which Mayo Clinic location will you be going to?