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I take Exemestane first thing in the morning. Been taking it since Nov 2024. This is the first time I've heard that it should be taken with a meal. Quick web search says taking Exemestane with meal helps avoid nausea--which I never get with it.
Web also mentions that less may be absorbed when no food is present in stomach. No medical oncologist has ever warned me about this . Is this true? Is there research on this? Many thanks in advance to anyone who knows!
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@peggydobbs I take it at lunch, as it breaks up the day and I am more active in the afternoon, than the morning. so I am not thinking about the medicine. Just about what I want to accomplish that day. I also take it with PROPEL with electrolytes, I have little to no side effects, once in a while I might have night sweats but, haven't pin pointed what I did differently that day to get night sweats. I do walking in the morning, and errands and gardening in the afternoons.
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@peggydobbs this one is a bit tricky. The reason I take with food is because the prescription says to take “after a meal”. This usually means the drug is fat soluble. Which means not absorbed well without food. HOWEVER if you read the research, there is negligible difference in amount absorbed with or without fat. One said take with high fat meal for best absorption but in the same article said to not take with high fat because it can increase dose amount. So back to the primary reason for us is to prevent stomach upset. I eat low fat (high protein) anyway so I take after food to prevent any stomach upset.