If there is a supplement that is on top of the "hits" chart of supplements for neuropathy, it is definitely ALA and that too R-ALA. BTW, I hear that in Europe ALA is the standard medical treatment for PN - administered intrevenously. I have tried 7-8 different supplements so far - most of them appear to help for a while and then they lose their effect. I had taken ALA 5 years ago and it was quite helpful in mitigating the pins and needles. Then it stopped being effective. I gave ALA a few year break and now trying out again (600 mg once a day). I have not seen any impact so far. It would also be fair to point out that most references for use of ALA are for diabetic neuropathy which is not my case. It would be nice if there was credible research on supplements for PN. I have seen any.