@bionicbeckyrocks would your doctor consider a dose reduction of Tagrisso? my oncologists have opposed it, but I have seen posts from many women saying they felt better and were able to continue on 40mg instead of 80. as far as Rybrevant - if you decide to try it, I would absolutely make sure you receive the corresponding dermatological protocol. there's a lung cancer oncologist in Colorado who got lung cancer himself and shared his experience with it (around minute 18 in the video.) do you have support as you make these tough decisions?