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Bones, Joints & Muscles | Last Active: Jun 11 7:33pm | Replies (104)
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@mnsansei how much colchicine did you take? Newly diagnosed CPPD after over 10 years. I started .6mg daily and it didn’t help my chronic Pseudogout at all after 4 weeks. I asked for increase in dose and doc stopped it and started plaquenil a week ago. It might take 6 months to work. I too can’t take nsaids but I’ve had to sneak 600mg every now and then. It’s the only thing that works. I’m afraid this doc , even though he was the only one that took the time to look at my old X-rays and found the crystals, May not be an expert on treatment.
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@jonijean On Day 1 I took 1.2 mg and after that, 0.6 mg/day on my local nephrologist's advice. The rationale is that half of the colchicine taken is eliminated from your body in about 24 hours. So before taking the 0.6 mg on Day 2, you have 0.6 mg left in you (and, of course, are back up to 1.2 mg after taking it). If you take 0.6 mg at about the same time every day, it will be like starting from scratch every day.
If my calculation is correct, if you take 0.6 mg on Day 1 and every subsequent day, you will plateau at about 0.6 mg on Day 5. I wonder if your doctor would let you give my nephrologist's dosing strategy (1.2 mg on Day 1 and 0.6 mg per day from then on) a whirl.
I take 0.6 mg colchicine every day. I get fairly good pain relief.
The only OTC analgesic I take is tylenol (even that is more limited that most people are allowed to take). Generally speaking, it is not worth taking tylenol. I am not familiar with plaquenil but google suggests it would be okay for me to take. I'll keep that in mind in case colchicine quits working.
Good luck.